Are Antidepressants toxic to dogs?

High severity No safe amount — No amount is considered safe.

Yes, Antidepressants are highly toxic to dogs. Exposure can cause serious illness and needs prompt veterinary attention. No amount is considered safe.

Symptoms to watch for

sedation
central nervous system stimulation
anorexia
lethargy
serotonin syndrome
vomiting
tremoring
seizures
hyperthermia
diarrhea
abdominal pain
dilated pupils

How vets treat it

Immediate veterinary attention is required for decontamination, sedation, thermoregulation, IV fluid therapy, and monitoring of blood pressure and heart rhythm (ECG).

Why it's dangerous

These medications increase serotonin levels in the body, which at high doses can lead to serotonin syndrome, causing central nervous system stimulation or sedation and autonomic instability.

Toxic compound: Selective serotonin reuptake inhibitors (SSRIs)

Good to know

Even therapeutic doses can result in moderate to severe clinical signs; rapid onset of symptoms makes professional decontamination essential.

Sources

Pet Poison Helpline

This page is informational and is not veterinary advice. If your pet has been exposed to something risky, contact your vet or an animal poison control line right away.

The StrawPaw Team · How we prepare our guides

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